Frank Lester Greene (February 10, 1870 - December 17, 1930) was a United States Representative and Senator from Vermont. Born in St. Albans, Vermont, he attended the public schools and was employed by the Central Vermont Railway Co. in various capacities from 1883 to 1891. He served in the Vermont National Guard from 1888 to 1900, rising from private to captain; during the Spanish-American War he recruited an infantry company, serving as captain. He was mustered out and commissioned colonel on the staff of the Governor. From 1891 to 1912 he was reporter and later editor of the St. Albans Daily Messenger, and was president of the Vermont Press Association, 1904-1905. He was a member of the commission to prepare and propose amendments to the Vermont Constitution in 1908.
Greene was elected as a Republican to the Sixty-second Congress to fill the vacancy caused by the death of David J. Foster, and was reelected to the Sixty-third and to the four succeeding Congresses, serving from July 30, 1912, until March 3, 1923. He was regent of the Smithsonian Institution from 1917 to 1923, and in 1922 he was elected to the U.S. Senate. Greene was reelected in 1928 and served from March 4, 1923, until his death in St. Albans in 1930. While in the Senate, he was chairman of the Committee on Enrolled Bills (Sixty-ninth through Seventy-first Congresses). His remains were interred in Greenwood Cemetery.