John Holmes Prentiss (April 17, 1784 - June 26, 1861) was a United States Representative from New York. Born in Worcester, Massachusetts, he attended local and private schools. He was foreman of the New York Evening Post in 1808 and moved to Cooperstown, New York in October 1808; he established the Freeman's Journal in the same year and served as its editor. Prentiss was appointed colonel of militia by Governor Clinton and served as division inspector on the staff of the commander in chief. He was postmaster of Cooperstown from April 24, 1833, to February 17, 1837 and was vice president of the Democratic State convention at Albany.
Prentiss was elected as a Democrat to the Twenty-fifth and Twenty-sixth Congresses, serving from March 4, 1837 to March 3, 1841; he was not a candidate for renomination in 1840 and resumed his former newspaper pursuits. He also served as president of the Bank of Cooperstown, and resided there until his death in that city in 1861. Interment was in Lakewood Cemetery.
John Holmes Prentiss' brother, Samuel Prentiss, was a U.S. Senator and United States District Court judge from Vermont.