Johnny Sain (born September 25, 1917) was an American Major League Baseball player. He pitched for 11 years, winning 136 and losing 116 games in his career.
His best years were those immediately after World War II, when he won 100 games for the Boston Braves before being traded to the New York Yankees during the 1951 season for Lew Burdette and cash. In 1948, he won 24 games, lost only 15, and finished second in the voting for that year's MVP Award. He and teammate Warren Spahn achieved joint immortality that year when their feats were the subject of a poem in the Boston Post which was eventually shortened to the epigram, "Spahn and Sain and pray for rain."
After retiring as a player, Sain spent many years as a well-regarded pitching coach.