Nathan B. Scott (December 18, 1842 - January 2, 1924) was a United States Senator from West Virginia. Born near Quaker City, Ohio, he attended the common schools and engaged in mining near Colorado Springs, Colorado from 1859 to 1862. During the Civil War he entered the Union Army in 1863 as a corporal and was appointed sergeant in 1864, promoted to regimental commissary sergeant in 1865, and mustered out in 1865. After the war he engaged in the manufacture of glass in Wheeling, West Virginia and also engaged in banking. He was a member and president of the city council from 1881 to 1883. From 1883 to 1890 he was a member of the West Virginia Senate and in 1888 he was a member of the Republican National Committee.
Scott was appointed Commissioner of Internal Revenue by President William McKinley in 1898, and served until February 1899, when he resigned to become a U.S. Senator; he had been elected as a Republican in 1899 and was reelected in 1905, serving from March 4, 1899, to March 3, 1911. He was an unsuccessful candidate for renomination. While in the Senate, he was chairman of the Committee on Mines and Mining (Fifty-seventh through Fifty-ninth Congresses) and a member of the Committee on Public Buildings and Grounds (Fifty-ninth through Sixty-first Congresses). Scott was appointed a member of the Lincoln Memorial Commission in 1911 and engaged in banking in Washington, D.C. until his death in 1924. The remains were cremated and the ashes deposited in a mausoleum in Rock Creek Cemetery, Washington, D.C.