Thomas Buck Reed (May 7, 1787 - November 26, 1829) was a United States Senator from Mississippi. Born near Lexington, Kentucky, he attended the public schools and the College of New Jersey (now Princeton University.) He studied law, was admitted to the bar and commenced practice in Lexington in 1808; in 1809 he moved to Natchez, Mississippi and was city clerk in 1811. He was an unsuccessful candidate for Delegate to Congress in 1813, and was attorney general of Mississippi from 1821 to 1826.
In 1825, Reed was elected to the Mississippi House of Representatives but declined to take his seat; he was elected to the U.S. Senate to fill the vacancy caused by the resignation of David Holmes and served from January 28, 1826, to March 3, 1827. He was an unsuccessful candidate for reelection in 1827, but was again elected to the Senate in 1828 and served from March 4, 1829, until his death in Lexington, Kentucky in 1829. Interment was in the Old Baptist Cemetery.
Reed's party affiliation was Jacksonian.